The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension

Yuyao Wang; Jingzhou Chen; Weihua Song; Yuxuan Wang; Yu Chen; Yu Nie; Rutai Hui

doi:10.1371/journal.pone.0135526

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Open Access

Peer-reviewed

Research Article

The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension

Yuyao Wang ,

* E-mail: wyybio@163.com (YYW); huirutai@gmail.com (RTH)

Affiliations Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China, Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Jingzhou Chen,

Affiliation Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Weihua Song,

Affiliation Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Yuxuan Wang,

Affiliation Department of Thoracic Surgery, Shanxi Dayi Hospital, Taiyuan, China
⨯
Yu Chen,

Affiliation Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Yu Nie,

Affiliation Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Rutai Hui

* E-mail: wyybio@163.com (YYW); huirutai@gmail.com (RTH)

Affiliation Sino-German Laboratory for Molecular Medicine, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

The Human Myotrophin Variant Attenuates MicroRNA-Let-7 Binding Ability but Not Risk of Left Ventricular Hypertrophy in Human Essential Hypertension

Yuyao Wang,
Jingzhou Chen,
Weihua Song,
Yuxuan Wang,
Yu Chen,
Yu Nie,
Rutai Hui

Published: August 14, 2015
https://doi.org/10.1371/journal.pone.0135526

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