Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly by a High-Output State Rather Than Elevated Pulmonary Vascular Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study

Sitali Mushemi-Blake; Narbeh Melikian; Emma Drasar; Amit Bhan; Alan Lunt; Sujal R. Desai; Anne Greenough; Mark J. Monaghan; Swee Lay Thein; Ajay M. Shah

doi:10.1371/journal.pone.0135472

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Peer-reviewed

Research Article

Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly by a High-Output State Rather Than Elevated Pulmonary Vascular Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study

Sitali Mushemi-Blake,

Affiliations King’s College London British Heart Foundation Centre, Cardiovascular Division, London, United Kingdom, Department of Cardiology, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Narbeh Melikian,

Affiliations King’s College London British Heart Foundation Centre, Cardiovascular Division, London, United Kingdom, Department of Cardiology, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Emma Drasar,

Affiliation Department of Haematological Medicine, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Amit Bhan,

Affiliation Department of Cardiology, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Alan Lunt,

Affiliation Department of Paediatrics, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Sujal R. Desai,

Affiliation Department of Radiology, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Anne Greenough,

Affiliation Department of Paediatrics, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Mark J. Monaghan,

Affiliations King’s College London British Heart Foundation Centre, Cardiovascular Division, London, United Kingdom, Department of Cardiology, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯
Swee Lay Thein,

Affiliations Department of Haematological Medicine, King’s College Hospital, Denmark Hill, London, United Kingdom, NIH / National Institute of Heart, Lung and Blood Diseases, Sickle Cell Branch, Bethesda, Maryland, United States of America
⨯
Ajay M. Shah

* E-mail: ajay.shah@kcl.ac.uk

Affiliations King’s College London British Heart Foundation Centre, Cardiovascular Division, London, United Kingdom, Department of Cardiology, King’s College Hospital, Denmark Hill, London, United Kingdom
⨯

Pulmonary Haemodynamics in Sickle Cell Disease Are Driven Predominantly by a High-Output State Rather Than Elevated Pulmonary Vascular Resistance: A Prospective 3-Dimensional Echocardiography/Doppler Study

Sitali Mushemi-Blake,
Narbeh Melikian,
Emma Drasar,
Amit Bhan,
Alan Lunt,
Sujal R. Desai,
Anne Greenough,
Mark J. Monaghan,
Swee Lay Thein,
Ajay M. Shah

Published: August 13, 2015
https://doi.org/10.1371/journal.pone.0135472

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26 Aug 2015
14:43 GMT
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A welcome confirmation of previous work in children Posted by suzcro on 26 Aug 2015 at 08:47 GMT

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