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Open Access
Peer-reviewed
Research Article
High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer’s Disease in Human Cerebrospinal Fluid
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Ronald C. Hendrickson ,
Contributed equally to this work with: Ronald C. Hendrickson, Nathan A. Yates
* E-mail: hendricr@mskcc.org
Current Address: Memorial Sloan Kettering Cancer Center, New York, NY, United States of America,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Anita Y. H. Lee,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Qinghua Song,
Current Address: Gilead, San Francisco, CA, United States of America,
Affiliation Biometrics, Merck & Co., Rahway, NJ, United States of America
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Andy Liaw,
Affiliation Biometrics, Merck & Co., Rahway, NJ, United States of America
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Matt Wiener,
Affiliation Applied Computer Science and Mathematics, Merck & Co., Rahway, NJ, United States of America
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Cloud P. Paweletz,
Current Address: Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, MA, United States of America,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Jeffrey L. Seeburger,
Affiliation Clinical Neuroscience and Ophthalmology, Merck & Co., West Point, PA, United States of America
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Jenny Li,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Fanyu Meng,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Ekaterina G. Deyanova,
Current Address: Bristol Myers Squibb, Princeton, NJ, United States of America,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Matthew T. Mazur,
Current Address: Imclone, New York, NY, United States of America,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Robert E. Settlage,
Current Address: Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, VA, United States of America,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Xuemei Zhao,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Katie Southwick,
Current Address: ThermoFisher Scientific, San Jose, CA, United States of America,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Yi Du,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Dan Holder,
Affiliation Biometrics, Merck & Co., West Point, PA, United States of America
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Jeffrey R. Sachs,
Affiliation Applied Computer Science and Mathematics, Merck & Co., Rahway, NJ, United States of America
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Omar F. Laterza,
Affiliation Clinical Development Laboratory, Merck & Co., Rahway, NJ, United States of America
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Aimee Dallob,
Affiliation Clinical Development Laboratory, Merck & Co., Rahway, NJ, United States of America
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Derek L. Chappell,
Affiliation Clinical Development Laboratory, Merck & Co., Rahway, NJ, United States of America
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Karen Snyder,
Affiliation Clinical Development Laboratory, Merck & Co., Rahway, NJ, United States of America
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Vijay Modur,
Current Address: Genzyme, Cambridge, MA, United States of America,
Affiliation Neuroscience Basic Research, Merck & Co., West Point, PA, United States of America
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Elizabeth King,
Affiliation OPTIMA, University of Oxford, Department of Pharmacology, Oxford United Kingdom
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Catharine Joachim,
Affiliation OPTIMA, University of Oxford, Department of Pharmacology, Oxford United Kingdom
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Andrey Y. Bondarenko,
Current Address: InfoClinika, Seattle, WA, United States of America,
Affiliation Rosetta Biosoftware, Seattle, WA, United States of America
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Mark Shearman,
Current Address: Applied Genetic Technologies Corporation, Boston, MA, United States of America,
Affiliation Neuroscience Basic Research, Merck & Co., West Point, PA, United States of America
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Keith A. Soper,
Affiliation Biometrics, Merck & Co., West Point, PA, United States of America
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A. David Smith,
Affiliation OPTIMA, University of Oxford, Department of Pharmacology, Oxford United Kingdom
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William Z. Potter,
Affiliation Clinical Neuroscience and Ophthalmology, Merck & Co., West Point, PA, United States of America
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Ken S. Koblan,
Affiliation Neuroscience Basic Research, Merck & Co., West Point, PA, United States of America
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Alan B. Sachs,
Current Address: ThermoFisher Scientific, Carlsbad, CA, United States of America,
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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Nathan A. Yates
Contributed equally to this work with: Ronald C. Hendrickson, Nathan A. Yates
Current Address: University of Pittsburg School of Medicine, Pittsburgh, PA, United States of America
Affiliation Departments of Exploratory and Translational Sciences, Merck & Co., Rahway, NJ, United States of America
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High Resolution Discovery Proteomics Reveals Candidate Disease Progression Markers of Alzheimer’s Disease in Human Cerebrospinal Fluid
- Ronald C. Hendrickson,
- Anita Y. H. Lee,
- Qinghua Song,
- Andy Liaw,
- Matt Wiener,
- Cloud P. Paweletz,
- Jeffrey L. Seeburger,
- Jenny Li,
- Fanyu Meng,
- Ekaterina G. Deyanova
- Published: August 13, 2015
- https://doi.org/10.1371/journal.pone.0135365