Promoter Hypomethylation of Maspin Inhibits Migration and Invasion of Extravillous Trophoblast Cells during Placentation

Xinwei Shi; Hao Liu; Jing Cao; Qing Liu; Guiju Tang; Wanlu Liu; Haiyi Liu; Dongrui Deng; Fuyuan Qiao; Yuanyuan Wu

doi:10.1371/journal.pone.0135359

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Open Access

Peer-reviewed

Research Article

Promoter Hypomethylation of Maspin Inhibits Migration and Invasion of Extravillous Trophoblast Cells during Placentation

Xinwei Shi,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Hao Liu,

Affiliation Department of Urology, Wuhan Third Hospital, guanggu on campus, Wuhan, Hubei, China
⨯
Jing Cao,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Qing Liu,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Guiju Tang,

Affiliation Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Wanlu Liu,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Haiyi Liu,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Dongrui Deng,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Fuyuan Qiao,

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯
Yuanyuan Wu

* E-mail: qianmei98@163.com

Affiliation Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
⨯

Promoter Hypomethylation of Maspin Inhibits Migration and Invasion of Extravillous Trophoblast Cells during Placentation

Xinwei Shi,
Hao Liu,
Jing Cao,
Qing Liu,
Guiju Tang,
Wanlu Liu,
Haiyi Liu,
Dongrui Deng,
Fuyuan Qiao,
Yuanyuan Wu

Published: August 11, 2015
https://doi.org/10.1371/journal.pone.0135359

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DNA methylation
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Hypoxia
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Recombinant proteins
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Protein expression
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Trophoblasts
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Apoptosis
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Breast cancer
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Promoter regions
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