Radiation-Induced Glycogen Accumulation Detected by Single Cell Raman Spectroscopy Is Associated with Radioresistance that Can Be Reversed by Metformin

• Quinn Matthews,

  Affiliations Trev and Joyce Deeley Research Centre, BC Cancer Agency, Victoria, BC, Canada, Department of Medical Physics, BC Cancer Agency, Victoria, BC, Canada

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• Martin Isabelle,

  Affiliations Trev and Joyce Deeley Research Centre, BC Cancer Agency, Victoria, BC, Canada, Department of Physics and Astronomy, University of Victoria, Victoria, BC, Canada

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• Samantha J. Harder,

  Affiliation Department of Physics and Astronomy, University of Victoria, Victoria, BC, Canada

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• Julian Smazynski,

  Affiliation Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada

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• Wayne Beckham,

  Affiliations Department of Physics and Astronomy, University of Victoria, Victoria, BC, Canada, Department of Medical Physics, BC Cancer Agency, Victoria, BC, Canada

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• Alexandre G. Brolo,

  Affiliation Department of Chemistry, University of Victoria, Victoria, BC, Canada

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• Andrew Jirasek ,

  * E-mail: jjlum@bccancer.bc.ca (JLL); andrew.jirasek@ubc.ca (AJ)

  Affiliation Mathematics, Statistics, Physics, and Computer Science, University of British Columbia Okanagan, Kelowna, BC, Canada

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• Julian J. Lum

  * E-mail: jjlum@bccancer.bc.ca (JLL); andrew.jirasek@ubc.ca (AJ)

  Affiliations Trev and Joyce Deeley Research Centre, BC Cancer Agency, Victoria, BC, Canada, Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada

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