Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia

Laura B. Ramsey; Laura J. Janke; Monique A. Payton; Xiangjun Cai; Steven W. Paugh; Seth E. Karol; Landry Kamdem Kamdem; Cheng Cheng; Richard T. Williams; Sima Jeha; Ching-Hon Pui; William E. Evans; Mary V. Relling

doi:10.1371/journal.pone.0135134

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Open Access

Peer-reviewed

Research Article

Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia

Laura B. Ramsey,

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Laura J. Janke,

Affiliation Department of Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Monique A. Payton,

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Xiangjun Cai,

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Steven W. Paugh,

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Seth E. Karol,

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Landry Kamdem Kamdem,

Affiliation Harding University College of Pharmacy, Searcy, Arkansas, United States of America
⨯
Cheng Cheng,

Affiliation Biostatistics Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Richard T. Williams,

Affiliation Puma Biotechnology Inc., Los Angeles, California, United States of America
⨯
Sima Jeha,

Affiliation Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Ching-Hon Pui,

Affiliation Department of Oncology, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
William E. Evans,

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯
Mary V. Relling

* E-mail: mary.relling@stjude.org

Affiliation Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, Tennessee, United States of America
⨯

Antileukemic Efficacy of Continuous vs Discontinuous Dexamethasone in Murine Models of Acute Lymphoblastic Leukemia

Laura B. Ramsey,
Laura J. Janke,
Monique A. Payton,
Xiangjun Cai,
Steven W. Paugh,
Seth E. Karol,
Landry Kamdem Kamdem,
Cheng Cheng,
Richard T. Williams,
Sima Jeha

Published: August 7, 2015
https://doi.org/10.1371/journal.pone.0135134

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