An Origin of Cooperative Oxygen Binding of Human Adult Hemoglobin: Different Roles of the α and β Subunits in the α₂β₂ Tetramer

• Shigenori Nagatomo ,

  Contributed equally to this work with: Shigenori Nagatomo, Yukifumi Nagai, Yayoi Aki, Teizo Kitagawa, Masako Nagai

  * E-mail: nagatomo@chem.tsukuba.ac.jp (SN); teizo@sci.u-hyogo.ac.jp (TK); masako.nagai.34@hosei.ac.jp (MN)

  Affiliation Department of Chemistry, University of Tsukuba, Tsukuba, Ibaraki, Japan

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• Yukifumi Nagai ,

  Contributed equally to this work with: Shigenori Nagatomo, Yukifumi Nagai, Yayoi Aki, Teizo Kitagawa, Masako Nagai

  Affiliation Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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• Yayoi Aki ,

  Contributed equally to this work with: Shigenori Nagatomo, Yukifumi Nagai, Yayoi Aki, Teizo Kitagawa, Masako Nagai

  Affiliation Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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• Hiroshi Sakurai,

  Affiliation Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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• Kiyohiro Imai,

  Affiliation Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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• Naoki Mizusawa,

  Affiliations Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan, Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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• Takashi Ogura,

  Affiliation Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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• Teizo Kitagawa ,

  Contributed equally to this work with: Shigenori Nagatomo, Yukifumi Nagai, Yayoi Aki, Teizo Kitagawa, Masako Nagai

  * E-mail: nagatomo@chem.tsukuba.ac.jp (SN); teizo@sci.u-hyogo.ac.jp (TK); masako.nagai.34@hosei.ac.jp (MN)

  Affiliation Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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• Masako Nagai

  Contributed equally to this work with: Shigenori Nagatomo, Yukifumi Nagai, Yayoi Aki, Teizo Kitagawa, Masako Nagai

  * E-mail: nagatomo@chem.tsukuba.ac.jp (SN); teizo@sci.u-hyogo.ac.jp (TK); masako.nagai.34@hosei.ac.jp (MN)

  Affiliations Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan, Research Center for Micro-Nano Technology, Hosei University, Koganei, Tokyo, Japan,3 School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan,4 Department of Frontier Biosciences, Hosei University, Koganei, Tokyo, Japan,5 Picobiology Institute, Graduate School of Life Science, University of Hyogo, RSC-UH Leading Program Center, Sayo, Sayo-gun, Hyogo, Japan

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