High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution

Emanuela Carlotti; David Wrench; Guglielmo Rosignoli; Jacek Marzec; Ajanthah Sangaralingam; Lena Hazanov; Miri Michaeli; Simon Hallam; Tracy Chaplin; Sameena Iqbal; Maria Calaminici; Bryan Young; Ramit Mehr; Peter Campbell; Jude Fitzgibbon; John G. Gribben

doi:10.1371/journal.pone.0134833

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Peer-reviewed

Research Article

High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution

Emanuela Carlotti,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
David Wrench,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Guglielmo Rosignoli,

Affiliation Flow Cytometry Core Facility, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Jacek Marzec,

Affiliation Centre for Molecular Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Ajanthah Sangaralingam,

Affiliation Centre for Molecular Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Lena Hazanov,

Affiliation The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
⨯
Miri Michaeli,

Affiliation The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
⨯
Simon Hallam,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Tracy Chaplin,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Sameena Iqbal,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Maria Calaminici,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Bryan Young,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
Ramit Mehr,

Affiliation The Mina & Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel
⨯
Peter Campbell,

Affiliation Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom
⨯
Jude Fitzgibbon,

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
[ ... ],
John G. Gribben

* E-mail: j.gribben@qmul.ac.uk

Affiliation Centre for Haemato-Oncology, Barts Cancer Institute - a CR-UK Centre Of Excellence, Queen Mary University of London, London, United Kingdom
⨯
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High Throughput Sequencing Analysis of the Immunoglobulin Heavy Chain Gene from Flow-Sorted B Cell Sub-Populations Define the Dynamics of Follicular Lymphoma Clonal Evolution

Emanuela Carlotti,
David Wrench,
Guglielmo Rosignoli,
Jacek Marzec,
Ajanthah Sangaralingam,
Lena Hazanov,
Miri Michaeli,
Simon Hallam,
Tracy Chaplin,
Sameena Iqbal

Published: September 1, 2015
https://doi.org/10.1371/journal.pone.0134833

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