17β-Hydroxysteroid Dehydrogenase Type 2 Inhibition: Discovery of Selective and Metabolically Stable Compounds Inhibiting Both the Human Enzyme and Its Murine Ortholog

• Emanuele M. Gargano,

  Affiliation Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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• Giuseppe Allegretta,

  Affiliation Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany

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• Enrico Perspicace,

  Affiliation Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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• Angelo Carotti,

  Affiliation Dipartimento Farmaco-Chimico, Università degli Studi di Bari, Bari, Italy

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• Chris Van Koppen,

  Affiliation ElexoPharm GmbH, Saarbrücken, Germany

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• Martin Frotscher,

  Affiliation Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany

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• Sandrine Marchais-Oberwinkler ,

  * E-mail: rolf.hartmann@helmoltz-hzi.de (RWH); s.marchais@mx.uni-saarland.de (SMO)

  Affiliations Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany

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• Rolf W. Hartmann

  * E-mail: rolf.hartmann@helmoltz-hzi.de (RWH); s.marchais@mx.uni-saarland.de (SMO)

  Affiliations Pharmaceutical and Medicinal Chemistry, Saarland University, Saarbrücken, Germany, Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany

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