The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

Lakshmi Ganapathi; Simon Van Haren; David J. Dowling; Ilana Bergelson; Nikunj M. Shukla; Subbalakshmi S. Malladi; Rajalakshmi Balakrishna; Hiromi Tanji; Umeharu Ohto; Toshiyuki Shimizu; Sunil A. David; Ofer Levy

doi:10.1371/journal.pone.0134640

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Peer-reviewed

Research Article

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

Lakshmi Ganapathi,

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America
⨯
Simon Van Haren,

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America
⨯
David J. Dowling,

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America
⨯
Ilana Bergelson,

Affiliation Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United States of America
⨯
Nikunj M. Shukla,

Affiliation Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America
⨯
Subbalakshmi S. Malladi,

Affiliation Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America
⨯
Rajalakshmi Balakrishna,

Affiliation Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America
⨯
Hiromi Tanji,

Affiliation Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
⨯
Umeharu Ohto,

Affiliation Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
⨯
Toshiyuki Shimizu,

Affiliation Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
⨯
Sunil A. David,

Affiliation Department of Medicinal Chemistry, University of Kansas, Lawrence, KS, United States of America
⨯
Ofer Levy

* E-mail: ofer.levy@childrens.harvard.edu

Affiliations Division of Infectious Diseases, Boston Children’s Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America
⨯

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

Lakshmi Ganapathi,
Simon Van Haren,
David J. Dowling,
Ilana Bergelson,
Nikunj M. Shukla,
Subbalakshmi S. Malladi,
Rajalakshmi Balakrishna,
Hiromi Tanji,
Umeharu Ohto,
Toshiyuki Shimizu

Published: August 14, 2015
https://doi.org/10.1371/journal.pone.0134640

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