Affinity Maturation of Monoclonal Antibody 1E11 by Targeted Randomization in CDR3 Regions Optimizes Therapeutic Antibody Targeting of HER2-Positive Gastric Cancer

Open Access

Peer-reviewed

Research Article

Bong-Kook Ko,

Affiliation Therapeutic antibody research center, AbClon Inc., Seoul, Korea
⨯
Soyoung Choi,

Affiliation Therapeutic antibody research center, AbClon Inc., Seoul, Korea
⨯
Lei Guang Cui,

Affiliation Therapeutic antibody research center, AbClon Inc., Seoul, Korea
⨯
Young-Ha Lee,

Affiliation Therapeutic antibody research center, AbClon Inc., Seoul, Korea
⨯
In-Sik Hwang,

Affiliation Therapeutic antibody research center, AbClon Inc., Seoul, Korea
⨯
Kyu-Tae Kim ,

* E-mail: hshim@ewha.ac.kr (HS); ktkim@abclon.com (KTK)

Affiliation Therapeutic antibody research center, AbClon Inc., Seoul, Korea
⨯
Hyunbo Shim ,

* E-mail: hshim@ewha.ac.kr (HS); ktkim@abclon.com (KTK)

Affiliation Departments of Bioinspired Science and Life Science, Ewha Womans University, Seoul, Korea
⨯
Jong-Seo Lee

Affiliation Therapeutic antibody research center, AbClon Inc., Seoul, Korea
⨯

Reader Comments (0)

Cloning
Is the Subject Area "Cloning" applicable to this article?

Thanks for your feedback.
Antibody therapy
Is the Subject Area "Antibody therapy" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Gastric cancer
Is the Subject Area "Gastric cancer" applicable to this article?

Thanks for your feedback.
Alanine scanning
Is the Subject Area "Alanine scanning" applicable to this article?

Thanks for your feedback.
Binding analysis
Is the Subject Area "Binding analysis" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.