Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells

Hye Rin Lee; Hwa Kyoung Shin; So Youn Park; Hye Young Kim; Sun Sik Bae; Won Suk Lee; Byung Yong Rhim; Ki Whan Hong; Chi Dae Kim

doi:10.1371/journal.pone.0134486

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Open Access

Peer-reviewed

Research Article

Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells

Hye Rin Lee,

Affiliations Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯
Hwa Kyoung Shin,

Affiliation Division of Meridian and Structural Medicine, School of Korean Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯
So Youn Park,

Affiliations Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯
Hye Young Kim,

Affiliation Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯
Sun Sik Bae,

Affiliations Department of Pharmacology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea, Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯
Won Suk Lee,

Affiliation Department of Pharmacology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
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Byung Yong Rhim,

Affiliation Department of Pharmacology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯
Ki Whan Hong,

Affiliations Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯
Chi Dae Kim

* E-mail: chidkim@pusan.ac.kr

Affiliations Department of Pharmacology, School of Medicine, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea, Gene & Cell Therapy Research Center for Vessel-associated Diseases, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea, Medical Research Center for Ischemic Tissue Regeneration, Pusan National University, Yangsan-si, Gyeongsangnam-do, Republic of Korea
⨯

Cilostazol Upregulates Autophagy via SIRT1 Activation: Reducing Amyloid-β Peptide and APP-CTFβ Levels in Neuronal Cells

Hye Rin Lee,
Hwa Kyoung Shin,
So Youn Park,
Hye Young Kim,
Sun Sik Bae,
Won Suk Lee,
Byung Yong Rhim,
Ki Whan Hong,
Chi Dae Kim

Published: August 5, 2015
https://doi.org/10.1371/journal.pone.0134486

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