GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway

Barun Mahata; Soumika Biswas; Patricia Rayman; Ali Chahlavi; Jennifer Ko; Ashish Bhattacharjee; Yu-Teh Li; Yuntao Li; Tanya Das; Gaurisankar Sa; Baisakhi Raychaudhuri; Michael A. Vogelbaum; Charles Tannenbaum; James H. Finke; Kaushik Biswas

doi:10.1371/journal.pone.0134425

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Open Access

Peer-reviewed

Research Article

GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway

Barun Mahata ,

Contributed equally to this work with: Barun Mahata, Soumika Biswas

Affiliation Division of Molecular Medicine, Bose Institute, Kolkata, India
⨯
Soumika Biswas ,

Contributed equally to this work with: Barun Mahata, Soumika Biswas

Affiliation Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Patricia Rayman,

Affiliation Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Ali Chahlavi,

Affiliation Spine and Brain Institute, St. Vincent Medical Center, Jacksonville, Florida, United States of America
⨯
Jennifer Ko,

Affiliation Pathology Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Ashish Bhattacharjee,

Affiliation Department of Biotechnology, National Institute of Technology, Durgapur, India
⨯
Yu-Teh Li,

Affiliation Department of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, United States of America
⨯
Yuntao Li,

Affiliation Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Tanya Das,

Affiliations Division of Molecular Medicine, Bose Institute, Kolkata, India, Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Gaurisankar Sa,

Affiliations Division of Molecular Medicine, Bose Institute, Kolkata, India, Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Baisakhi Raychaudhuri,

Affiliation Brain Tumor and Neuro-oncology Center in the Neurological Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Michael A. Vogelbaum,

Affiliation Brain Tumor and Neuro-oncology Center in the Neurological Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Charles Tannenbaum,

Affiliation Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
⨯
James H. Finke,

Affiliation Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
⨯
Kaushik Biswas

* E-mail: kaushik@jcbose.ac.in

Affiliation Division of Molecular Medicine, Bose Institute, Kolkata, India
⨯

GBM Derived Gangliosides Induce T Cell Apoptosis through Activation of the Caspase Cascade Involving Both the Extrinsic and the Intrinsic Pathway

Barun Mahata,
Soumika Biswas,
Patricia Rayman,
Ali Chahlavi,
Jennifer Ko,
Ashish Bhattacharjee,
Yu-Teh Li,
Yuntao Li,
Tanya Das,
Gaurisankar Sa

Published: July 30, 2015
https://doi.org/10.1371/journal.pone.0134425

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T cells
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Sphingolipids
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Apoptosis
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