A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer’s Disease

Wasim Khan; Carlos Aguilar; Steven J. Kiddle; Orla Doyle; Madhav Thambisetty; Sebastian Muehlboeck; Martina Sattlecker; Stephen Newhouse; Simon Lovestone; Richard Dobson; Vincent Giampietro; Eric Westman; Andrew Simmons; Alzheimer’s Disease Neuroimaging Initiative

doi:10.1371/journal.pone.0134368

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Open Access

Peer-reviewed

Research Article

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer’s Disease

Wasim Khan ,

* E-mail: wasim.khan@kcl.ac.uk

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, NIHR Biomedical Research Centre for Mental Health, London, United Kingdom, NIHR Biomedical Research Unit for Dementia, London, United Kingdom
⨯
Carlos Aguilar,

Affiliation Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
⨯
Steven J. Kiddle,

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, NIHR Biomedical Research Centre for Mental Health, London, United Kingdom
⨯
Orla Doyle,

Affiliation King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom
⨯
Madhav Thambisetty,

Affiliation Laboratory of Behavioural Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Sebastian Muehlboeck,

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, NIHR Biomedical Research Centre for Mental Health, London, United Kingdom, NIHR Biomedical Research Unit for Dementia, London, United Kingdom
⨯
Martina Sattlecker,

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, NIHR Biomedical Research Centre for Mental Health, London, United Kingdom
⨯
Stephen Newhouse,

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, NIHR Biomedical Research Centre for Mental Health, London, United Kingdom
⨯
Simon Lovestone,

Affiliation Department of Psychiatry, University of Oxford, Oxford, United Kingdom
⨯
Richard Dobson,

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, NIHR Biomedical Research Centre for Mental Health, London, United Kingdom, NIHR Biomedical Research Unit for Dementia, London, United Kingdom
⨯
Vincent Giampietro,

Affiliation King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom
⨯
Eric Westman,

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
⨯
Andrew Simmons,

Affiliations King’s College London, Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom, NIHR Biomedical Research Centre for Mental Health, London, United Kingdom, NIHR Biomedical Research Unit for Dementia, London, United Kingdom
⨯
Alzheimer’s Disease Neuroimaging Initiative

A Subset of Cerebrospinal Fluid Proteins from a Multi-Analyte Panel Associated with Brain Atrophy, Disease Classification and Prediction in Alzheimer’s Disease

Wasim Khan,
Carlos Aguilar,
Steven J. Kiddle,
Orla Doyle,
Madhav Thambisetty,
Sebastian Muehlboeck,
Martina Sattlecker,
Stephen Newhouse,
Simon Lovestone,
Richard Dobson

Published: August 18, 2015
https://doi.org/10.1371/journal.pone.0134368

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Cerebrospinal fluid
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Alzheimer's disease
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Apolipoprotein genes
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Atrophy
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