Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes

Micheline Guillotte; Alexandre Juillerat; Sébastien Igonet; Audrey Hessel; Stéphane Petres; Elodie Crublet; Cécile Le Scanf; Anita Lewit-Bentley; Graham A. Bentley; Inès Vigan-Womas; Odile Mercereau-Puijalon

doi:10.1371/journal.pone.0134292

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Peer-reviewed

Research Article

Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes

Micheline Guillotte,

Affiliations Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France, Centre National de la Recherche Scientifique, Unité de recherche associée 2581, Paris, France
⨯
Alexandre Juillerat,

Affiliations Institut Pasteur, Unité d'Immunologie Structurale, Paris, France, Centre National de la Recherche Scientifique, Unité de recherche associée 2185, Paris, France
⨯
Sébastien Igonet,

Current address: Calixar SAS, Lyon, France

Affiliations Institut Pasteur, Unité d'Immunologie Structurale, Paris, France, Centre National de la Recherche Scientifique, Unité de recherche associée 2185, Paris, France
⨯
Audrey Hessel,

Current address: Institut de Biologie Structurale Jean-Pierre Ebel, Biomolecular NMR spectroscopy Group, Grenoble, France

Affiliations Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France, Institut Pasteur, Unité d'Immunologie Structurale, Paris, France
⨯
Stéphane Petres,

Affiliation Institut Pasteur, Plate-forme de Protéines recombinantes (PFPR), Paris, France
⨯
Elodie Crublet,

Current address: Institut de Biologie Structurale Jean-Pierre Ebel, Biomolecular NMR spectroscopy Group, Grenoble, France

Affiliation Institut Pasteur, Plate-forme de Protéines recombinantes (PFPR), Paris, France
⨯
Cécile Le Scanf,

Affiliation Bordeaux Biothèques Santé, Groupe hospitalier Pellegrin, Centre Hospitalier Universitaire de Bordeaux - Bordeaux, France
⨯
Anita Lewit-Bentley,

Affiliations Institut Pasteur, Unité d'Immunologie Structurale, Paris, France, Centre National de la Recherche Scientifique, Unité de recherche associée 2185, Paris, France
⨯
Graham A. Bentley,

Affiliations Institut Pasteur, Unité d'Immunologie Structurale, Paris, France, Centre National de la Recherche Scientifique, Unité de recherche associée 2185, Paris, France
⨯
Inès Vigan-Womas ,

Contributed equally to this work with: Inès Vigan-Womas, Odile Mercereau-Puijalon

Affiliations Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France, Centre National de la Recherche Scientifique, Unité de recherche associée 2581, Paris, France
⨯
Odile Mercereau-Puijalon

Contributed equally to this work with: Inès Vigan-Womas, Odile Mercereau-Puijalon

* E-mail:odile.puijalon@pasteur.fr

Affiliations Institut Pasteur, Unité d'Immunologie Moléculaire des Parasites, Paris, France, Centre National de la Recherche Scientifique, Unité de recherche associée 2581, Paris, France
⨯

Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes

Micheline Guillotte,
Alexandre Juillerat,
Sébastien Igonet,
Audrey Hessel,
Stéphane Petres,
Elodie Crublet,
Cécile Le Scanf,
Anita Lewit-Bentley,
Graham A. Bentley,
Inès Vigan-Womas

Published: July 29, 2015
https://doi.org/10.1371/journal.pone.0134292

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