Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway

Yang You; Qiongdan Zheng; Yinying Dong; Yaohui Wang; Lan Zhang; Tongchun Xue; Xiaoying Xie; Chao Hu; Zhiming Wang; Rongxin Chen; Yanhong Wang; Jiefeng Cui; Zhenggang Ren

doi:10.1371/journal.pone.0134243

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Open Access

Peer-reviewed

Research Article

Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway

Yang You,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Qiongdan Zheng,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Yinying Dong,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Yaohui Wang,

Affiliation Department of Interventional Radiology, Shanghai Cancer Center, Fudan University, Shanghai, 200032, PR China
⨯
Lan Zhang,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Tongchun Xue,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Xiaoying Xie,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Chao Hu,

Affiliation Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, PR China
⨯
Zhiming Wang,

Affiliation Department of Oncology, Zhongshan Hospital Subdivision, Fudan University, Shanghai, 200052, PR China
⨯
Rongxin Chen,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Yanhong Wang,

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Jiefeng Cui ,

* E-mail: ren.zhenggang@zs-hospital.sh.cn (ZGR); cui.jiefeng@zs-hospital.sh.cn (JFC)

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯
Zhenggang Ren

* E-mail: ren.zhenggang@zs-hospital.sh.cn (ZGR); cui.jiefeng@zs-hospital.sh.cn (JFC)

Affiliation Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 136 Xue Yuan Road, Shanghai, 200032, PR China
⨯

Higher Matrix Stiffness Upregulates Osteopontin Expression in Hepatocellular Carcinoma Cells Mediated by Integrin β1/GSK3β/β-Catenin Signaling Pathway

Yang You,
Qiongdan Zheng,
Yinying Dong,
Yaohui Wang,
Lan Zhang,
Tongchun Xue,
Xiaoying Xie,
Chao Hu,
Zhiming Wang,
Rongxin Chen

Published: August 17, 2015
https://doi.org/10.1371/journal.pone.0134243

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Integrins
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Stiffness
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Hepatocellular carcinoma
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Extracellular matrix
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