Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

Mayuka Nakajima; Kei Arimatsu; Tamotsu Kato; Yumi Matsuda; Takayoshi Minagawa; Naoki Takahashi; Hiroshi Ohno; Kazuhisa Yamazaki

doi:10.1371/journal.pone.0134234

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Peer-reviewed

Research Article

Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

Mayuka Nakajima,

Affiliations Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Kei Arimatsu,

Affiliations Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Tamotsu Kato,

Affiliation Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan
⨯
Yumi Matsuda,

Affiliations Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Takayoshi Minagawa,

Affiliations Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Naoki Takahashi,

Affiliations Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan, Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯
Hiroshi Ohno,

Affiliations Laboratory for Intestinal Ecosystem, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan, CREST, Japan Science and Technology Agency, Kawaguchi, Japan
⨯
Kazuhisa Yamazaki

* E-mail: kaz@dent.niigata-u.ac.jp

Affiliation Laboratory of Periodontology and Immunology, Division of Oral Science for Health Promotion, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
⨯

Oral Administration of P. gingivalis Induces Dysbiosis of Gut Microbiota and Impaired Barrier Function Leading to Dissemination of Enterobacteria to the Liver

Mayuka Nakajima,
Kei Arimatsu,
Tamotsu Kato,
Yumi Matsuda,
Takayoshi Minagawa,
Naoki Takahashi,
Hiroshi Ohno,
Kazuhisa Yamazaki

Published: July 28, 2015
https://doi.org/10.1371/journal.pone.0134234

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