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Open Access
Peer-reviewed
Research Article
Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma
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Sabelo Hadebe,
Affiliation Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Frank Kirstein,
Affiliation International Centre for Genetic Engineering and Biotechnology and Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Kaat Fierens,
Affiliation VIB Inflammation Research Center, Laboratory of Immunoregulation and Mucosal Immunology, University Ghent, Ghent, Belgium
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Kong Chen,
Affiliation Department of Paediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Rebecca A. Drummond,
Affiliation Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Simon Vautier,
Affiliation Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Sara Sajaniemi,
Affiliation Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Graeme Murray,
Affiliation Pathology, Division of Applied Medicine, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, United Kingdom
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David L. Williams,
Affiliation Department of Surgery and Center for Inflammation, Infectious Disease and Immunity, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
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Pierre Redelinghuys,
Affiliation Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Todd A. Reinhart,
Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Beth A. Fallert Junecko,
Affiliation Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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Jay K. Kolls,
Affiliation Department of Paediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
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Bart N. Lambrecht,
Affiliations VIB Inflammation Research Center, Laboratory of Immunoregulation and Mucosal Immunology, University Ghent, Ghent, Belgium, Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
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Frank Brombacher,
Affiliation International Centre for Genetic Engineering and Biotechnology and Division of Immunology, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Gordon D. Brown
* E-mail: gordon.brown@abdn.ac.uk
Affiliation Aberdeen Fungal Group, Infection, Immunity and Inflammation Programme, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Science, University of Cape Town, South Africa
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Microbial Ligand Costimulation Drives Neutrophilic Steroid-Refractory Asthma
- Sabelo Hadebe,
- Frank Kirstein,
- Kaat Fierens,
- Kong Chen,
- Rebecca A. Drummond,
- Simon Vautier,
- Sara Sajaniemi,
- Graeme Murray,
- David L. Williams,
- Pierre Redelinghuys
- Published: August 11, 2015
- https://doi.org/10.1371/journal.pone.0134219