Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis

Dongfeng Qu; Nathaniel Weygant; Randal May; Parthasarathy Chandrakesan; Mohammad Madhoun; Naushad Ali; Sripathi M. Sureban; Guangyu An; Michael J. Schlosser; Courtney W. Houchen

doi:10.1371/journal.pone.0134212

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Peer-reviewed

Research Article

Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis

Dongfeng Qu ,

Contributed equally to this work with: Dongfeng Qu, Nathaniel Weygant

Affiliations Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America, Department of Veterans Affairs Medical Center, Oklahoma City, OK, 73104, United States of America, Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City, OK, 73104, United States of America
⨯
Nathaniel Weygant ,

Contributed equally to this work with: Dongfeng Qu, Nathaniel Weygant

Affiliation Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America
⨯
Randal May,

Affiliations Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America, Department of Veterans Affairs Medical Center, Oklahoma City, OK, 73104, United States of America
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Parthasarathy Chandrakesan,

Affiliations Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America, Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City, OK, 73104, United States of America
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Mohammad Madhoun,

Affiliation Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America
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Naushad Ali,

Affiliations Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America, Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City, OK, 73104, United States of America
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Sripathi M. Sureban,

Affiliations Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America, Department of Veterans Affairs Medical Center, Oklahoma City, OK, 73104, United States of America, Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City, OK, 73104, United States of America
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Guangyu An,

Affiliation Department of Oncology, Beijing Chaoyang Hospital, Capitol Medicinal University, Beijing, 100020, China
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Michael J. Schlosser,

Affiliation COARE Biotechnology, Oklahoma City, OK, 73104, United States of America
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Courtney W. Houchen

* E-mail: Courtney-houchen@ouhsc.edu

Affiliations Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, United States of America, Department of Veterans Affairs Medical Center, Oklahoma City, OK, 73104, United States of America, Peggy and Charles Stephenson Oklahoma Cancer Center, Oklahoma City, OK, 73104, United States of America, COARE Biotechnology, Oklahoma City, OK, 73104, United States of America
⨯

Ablation of Doublecortin-Like Kinase 1 in the Colonic Epithelium Exacerbates Dextran Sulfate Sodium-Induced Colitis

Dongfeng Qu,
Nathaniel Weygant,
Randal May,
Parthasarathy Chandrakesan,
Mohammad Madhoun,
Naushad Ali,
Sripathi M. Sureban,
Guangyu An,
Michael J. Schlosser,
Courtney W. Houchen

Published: August 18, 2015
https://doi.org/10.1371/journal.pone.0134212

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