Which and How Many Patients Should Be Included in Randomised Controlled Trials to Demonstrate the Efficacy of Biologics in Primary Sjögren’s Syndrome?

• Valérie Devauchelle-Pensec,

  Affiliations Rheumatology Department, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609, Brest, France, EA 2216, INSERM ESPRI, ERI29 Université Bretagne Occidentale, 29200, Brest, France

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• Jacques-Eric Gottenberg,

  Affiliation Rheumatology Department, Strasbourg University Hospital, Strasbourg, France

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• Sandrine Jousse-Joulin,

  Affiliations Rheumatology Department, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609, Brest, France, EA 2216, INSERM ESPRI, ERI29 Université Bretagne Occidentale, 29200, Brest, France

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• Jean-Marie Berthelot,

  Affiliation Rheumatology Department, Hôtel-Dieu, CHU Nantes, 44093, Nantes Cedex 01, France

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• Aleth Perdriger,

  Affiliation Rheumatology Department, C.H.U. Hôpital Sud, 35000, Rennes, France

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• Eric Hachulla,

  Affiliation Internal Medicine Department, Claude Huriez Hospital, Lille2 University, 59037, Lille Cedex, France

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• Pierre Yves Hatron,

  Affiliation Internal Medicine Department, Claude Huriez Hospital, Lille2 University, 59037, Lille Cedex, France

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• Xavier Puechal,

  Affiliation Internal Medicine Department, Hôpital Cochin, Paris, France

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• Véronique Le Guern,

  Affiliation Internal Medicine Department, Hôpital Cochin, Paris, France

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• Jean Sibilia,

  Affiliation Rheumatology Department, Strasbourg University Hospital, Strasbourg, France

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• Laurent Chiche,

  Affiliation Internal Medicine Department, Hôpital de la Conception, 147 Bd Baille, 13005, Marseille, France

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• Vincent Goeb,

  Affiliation Rheumatology Department, C.H.R.U. d’Amiens, 76 230 Bois-Guillaume, France

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• Olivier Vittecoq,

  Affiliation Rheumatology Department, C.H.R.U. de Rouen, 76 230 Bois-Guillaume, France

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• Claire Larroche,

  Affiliation Internal Medicine Department, Bobigny University Hospital, Paris, France

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• Anne Laure Fauchais,

  Affiliation Internal Medicine Department, Limoges University Hospital, Limoges, France

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• Gilles Hayem,

  Affiliation Rheumatology Department, Ambroise Paré University Hospital, Paris, France

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• Jacques Morel,

  Affiliation Immuno-Rhumatology Department, C.H.U. Lapeyronie, 34295 Montpellier, France

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• Charles Zarnitsky,

  Affiliation Rheumatology Department, C.H. J. Monod, Montivilliers, France

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• Jean Jacques Dubost,

  Affiliation Rheumatology Department, Gabriel Montpied Teaching Hospital, Place H. Dunant, Clermont-Ferrand, 63000, France

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• Philippe Dieudé,

  Affiliation Rheumatology Department, Bichat Claude-Bernard Hospital, Paris, France

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• Jacques Olivier Pers,

  Affiliation EA 2216, INSERM ESPRI, ERI29 Université Bretagne Occidentale, 29200, Brest, France

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• Divi Cornec,

  Affiliations Rheumatology Department, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609, Brest, France, EA 2216, INSERM ESPRI, ERI29 Université Bretagne Occidentale, 29200, Brest, France

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• Raphaele Seror,

  Affiliation Rheumatology Department, Assistance Publique-Hôpitaux de Paris (AP-HP), INSERM U1012, Université Paris-Sud, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre, France

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• Xavier Mariette,

  Affiliation Rheumatology Department, Assistance Publique-Hôpitaux de Paris (AP-HP), INSERM U1012, Université Paris-Sud, 78 rue du Général Leclerc, 94275 Le Kremlin Bicêtre, France

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• Emmanuel Nowak,

  Affiliation INSERM CIC 0502, CHU Brest, Brest, France

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•  [ ... ],
• Alain Saraux

  * E-mail: alain.saraux@chu-brest.fr

  Affiliations Rheumatology Department, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609, Brest, France, EA 2216, INSERM ESPRI, ERI29 Université Bretagne Occidentale, 29200, Brest, France

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