Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells

Luyuan Li; Ana C. Paz; Breelyn A. Wilky; Britt Johnson; Karina Galoian; Andrew Rosenberg; Guozhi Hu; Gabriel Tinoco; Olaf Bodamer; Jonathan C. Trent

doi:10.1371/journal.pone.0133813

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Research Article

Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells

Luyuan Li,

Affiliations Division of Hematology and Oncology/Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Ana C. Paz,

Affiliations Division of Hematology and Oncology/Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Breelyn A. Wilky,

Affiliations Division of Hematology and Oncology/Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Britt Johnson,

Affiliation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Karina Galoian,

Affiliation Department of Orthopaedic Surgery, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Andrew Rosenberg,

Affiliation Department of Pathology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Guozhi Hu,

Affiliations Division of Hematology and Oncology/Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Gabriel Tinoco,

Affiliations Division of Hematology and Oncology/Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Olaf Bodamer,

Affiliation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯
Jonathan C. Trent

* E-mail: JTrent@med.miami.edu

Affiliations Division of Hematology and Oncology/Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America, Sheila and David Fuente Graduate Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
⨯

Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells

Luyuan Li,
Ana C. Paz,
Breelyn A. Wilky,
Britt Johnson,
Karina Galoian,
Andrew Rosenberg,
Guozhi Hu,
Gabriel Tinoco,
Olaf Bodamer,
Jonathan C. Trent

Published: September 14, 2015
https://doi.org/10.1371/journal.pone.0133813

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