Expression of Prostaglandin E₂ Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients

• Maria J. H. de Hair ,

  Contributed equally to this work with: Maria J. H. de Hair, Patrick Leclerc

  Affiliation Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Patrick Leclerc ,

  Contributed equally to this work with: Maria J. H. de Hair, Patrick Leclerc

  Affiliation Rheumatology research Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden

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• Elize C. Newsum,

  Affiliation Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Karen I. Maijer,

  Affiliation Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Marleen G. H. van de Sande,

  Affiliation Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Tamara H. Ramwadhdoebe,

  Affiliations Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands, Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Dirkjan van Schaardenburg,

  Affiliation Department of Rheumatology, Reade, Amsterdam, The Netherlands

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• Lisa G. M. van Baarsen,

  Affiliations Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands, Department of Experimental Immunology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Marina Korotkova,

  Affiliation Rheumatology research Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden

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• Danielle M. Gerlag,

  Current address: GlaxoSmithKline, Cambridge, United Kingdom.

  Affiliation Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Paul-Peter Tak ,

  * E-mail: paul-peter.x.tak@gsk.com

  Current address: GlaxoSmithKline, Stevenage, and University of Cambridge, Cambridge, United Kingdom.

  ¶‡ These authors also contributed equally to this work.

  Affiliation Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, the Netherlands

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• Per-Johan Jakobsson

  ¶‡ These authors also contributed equally to this work.

  Affiliation Rheumatology research Unit, Department of Medicine, Karolinska Institute, Stockholm, Sweden

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