Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice

Kenji Suita; Takayuki Fujita; Nozomi Hasegawa; Wenqian Cai; Huiling Jin; Yuko Hidaka; Rajesh Prajapati; Masanari Umemura; Utako Yokoyama; Motohiko Sato; Satoshi Okumura; Yoshihiro Ishikawa

doi:10.1371/journal.pone.0133664

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Peer-reviewed

Research Article

Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice

Kenji Suita ,

Contributed equally to this work with: Kenji Suita, Takayuki Fujita

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Takayuki Fujita ,

Contributed equally to this work with: Kenji Suita, Takayuki Fujita

* E-mail: fujitaka@yokohama-cu.ac.jp (TF); yishikaw@med.yokohama-cu.ac.jp (YI)

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Nozomi Hasegawa,

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Wenqian Cai,

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Huiling Jin,

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Yuko Hidaka,

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Rajesh Prajapati,

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Masanari Umemura,

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Utako Yokoyama,

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯
Motohiko Sato,

Affiliations Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan, Department of Physiology, Aichi Medical University School of Medicine, Aichi, Japan
⨯
Satoshi Okumura,

Affiliations Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan, Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan
⨯
Yoshihiro Ishikawa

* E-mail: fujitaka@yokohama-cu.ac.jp (TF); yishikaw@med.yokohama-cu.ac.jp (YI)

Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan
⨯

Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice

Kenji Suita,
Takayuki Fujita,
Nozomi Hasegawa,
Wenqian Cai,
Huiling Jin,
Yuko Hidaka,
Rajesh Prajapati,
Masanari Umemura,
Utako Yokoyama,
Motohiko Sato

Published: July 23, 2015
https://doi.org/10.1371/journal.pone.0133664

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Atrial fibrillation
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Muscle cells
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Mouse models
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Adrenergic signal transduction
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Intraperitoneal injections
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Norepinephrine
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