A Murine Myh6MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction

Jianyun Yan; Lu Zhang; Nishat Sultana; David S. Park; Akshay Shekhar; Lei Bu; Jun Hu; Shegufta Razzaque; Chen-Leng Cai

doi:10.1371/journal.pone.0133472

Loading metrics

Open Access

Peer-reviewed

Research Article

A Murine Myh6^MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction

Jianyun Yan ,

Contributed equally to this work with: Jianyun Yan, Lu Zhang, Nishat Sultana

Affiliation Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, and The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
Lu Zhang ,

Contributed equally to this work with: Jianyun Yan, Lu Zhang, Nishat Sultana

Affiliation Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, and The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
Nishat Sultana ,

Contributed equally to this work with: Jianyun Yan, Lu Zhang, Nishat Sultana

Affiliation Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, and The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
David S. Park,

Affiliation Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, United States of America
⨯
Akshay Shekhar,

Affiliation Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, United States of America
⨯
Lei Bu,

Affiliation Leon H. Charney Division of Cardiology, New York University School of Medicine, New York, NY, United States of America
⨯
Jun Hu,

Affiliation Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, and The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
Shegufta Razzaque,

Affiliation Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, and The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯
Chen-Leng Cai

* E-mail: chenleng.cai@mssm.edu

Affiliation Department of Developmental and Regenerative Biology, The Black Family Stem Cell Institute, and The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America
⨯

A Murine Myh6^MerCreMer Knock-In Allele Specifically Mediates Temporal Genetic Deletion in Cardiomyocytes after Tamoxifen Induction

Jianyun Yan,
Lu Zhang,
Nishat Sultana,
David S. Park,
Akshay Shekhar,
Lei Bu,
Jun Hu,
Shegufta Razzaque,
Chen-Leng Cai

Published: July 23, 2015
https://doi.org/10.1371/journal.pone.0133472

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Heart
Is the Subject Area "Heart" applicable to this article?

Thanks for your feedback.
Cardiomyocytes
Is the Subject Area "Cardiomyocytes" applicable to this article?

Thanks for your feedback.
Echocardiography
Is the Subject Area "Echocardiography" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
Genetically modified animals
Is the Subject Area "Genetically modified animals" applicable to this article?

Thanks for your feedback.
Cardiovascular physiology
Is the Subject Area "Cardiovascular physiology" applicable to this article?

Thanks for your feedback.
Gene targeting
Is the Subject Area "Gene targeting" applicable to this article?

Thanks for your feedback.