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Open Access

Peer-reviewed

Research Article

PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21

David E. Green ,

Contributed equally to this work with: David E. Green, Tamara C. Murphy, C. Michael Hart

* E-mail: degree4@emory.edu

Affiliation Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Atlanta Veterans Affairs Medical Center / Emory University, Atlanta, GA, United States of America
⨯
Tamara C. Murphy ,

Contributed equally to this work with: David E. Green, Tamara C. Murphy, C. Michael Hart

Affiliation Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Atlanta Veterans Affairs Medical Center / Emory University, Atlanta, GA, United States of America
⨯
Bum-Yong Kang ,

¶‡ These authors also contributed equally to this work.

Affiliation Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Atlanta Veterans Affairs Medical Center / Emory University, Atlanta, GA, United States of America
⨯
Charles D. Searles ,

¶‡ These authors also contributed equally to this work.

Affiliation Department of Medicine, Division of Cardiology, Atlanta Veterans Affairs Medical Center / Emory University, Atlanta, GA, United States of America
⨯
C. Michael Hart

Contributed equally to this work with: David E. Green, Tamara C. Murphy, C. Michael Hart

Affiliation Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Atlanta Veterans Affairs Medical Center / Emory University, Atlanta, GA, United States of America
⨯

PPARγ Ligands Attenuate Hypoxia-Induced Proliferation in Human Pulmonary Artery Smooth Muscle Cells through Modulation of MicroRNA-21

David E. Green,
Tamara C. Murphy,
Bum-Yong Kang,
Charles D. Searles,
C. Michael Hart

x

Published: July 24, 2015
https://doi.org/10.1371/journal.pone.0133391

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Hypoxia
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Transfection
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Mouse models
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Small interfering RNA
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MicroRNAs
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Pathogenesis
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Receptor antagonist therapy
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