Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo

Xianbin Cai; Xi Hu; Xiaojun Tan; Weijie Cheng; Qinjia Wang; Xiaofeng Chen; Yinghong Guan; Chong Chen; Xubin Jing

doi:10.1371/journal.pone.0133349

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Research Article

Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo

Xianbin Cai ,

Contributed equally to this work with: Xianbin Cai, Xi Hu

¶‡ These authors are co-first authors on this work.

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯
Xi Hu ,

Contributed equally to this work with: Xianbin Cai, Xi Hu

¶‡ These authors are co-first authors on this work.

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯
Xiaojun Tan,

Affiliation Department of Internal Medicine, Chancheng District Central Hospital, Foshan, Guangdong 528031, China
⨯
Weijie Cheng,

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯
Qinjia Wang,

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯
Xiaofeng Chen,

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯
Yinghong Guan,

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯
Chong Chen,

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯
Xubin Jing

* E-mail: xbjing@stu.edu.cn

Affiliation Department of Gastroenterology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515031, China
⨯

Metformin Induced AMPK Activation, G0/G1 Phase Cell Cycle Arrest and the Inhibition of Growth of Esophageal Squamous Cell Carcinomas In Vitro and In Vivo

Xianbin Cai,
Xi Hu,
Xiaojun Tan,
Weijie Cheng,
Qinjia Wang,
Xiaofeng Chen,
Yinghong Guan,
Chong Chen,
Xubin Jing

Published: July 21, 2015
https://doi.org/10.1371/journal.pone.0133349

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