The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells

Open Access

Peer-reviewed

Research Article

Hanjun Guan ,

* E-mail: hguan2@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Biomedical Biological Sciences Research Building, 741 South Limestone St., Lexington, KY, 40536–0509, United States of America
⨯
K. Martin Chow,

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Biomedical Biological Sciences Research Building, 741 South Limestone St., Lexington, KY, 40536–0509, United States of America
⨯
Eunsuk Song,

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Biomedical Biological Sciences Research Building, 741 South Limestone St., Lexington, KY, 40536–0509, United States of America
⨯
Nirmal Verma,

Affiliation Department of Molecular and Biomedical Pharmacology, University of Kentucky, 459 Wethington Bldg., 800 Rose St., Lexington, KY, 40536–0200, United States of America
⨯
Florin Despa,

Affiliation Department of Molecular and Biomedical Pharmacology, University of Kentucky, 459 Wethington Bldg., 800 Rose St., Lexington, KY, 40536–0200, United States of America
⨯
Louis B. Hersh

Affiliation Department of Molecular and Cellular Biochemistry, University of Kentucky, Biomedical Biological Sciences Research Building, 741 South Limestone St., Lexington, KY, 40536–0509, United States of America
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Mitochondria
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Apoptosis
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Oligomers
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Transfection
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Insulin
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Insulinoma
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Polypeptides
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Type 2 diabetes
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