Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

Kole T. Roybal; Emily M. Mace; Danielle J. Clark; Alan D. Leard; Andrew Herman; Paul Verkade; Jordan S. Orange; Christoph Wülfing

doi:10.1371/journal.pone.0133231

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Peer-reviewed

Research Article

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

Kole T. Roybal,

Current address: Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America

Affiliation Department of Immunology, UT Southwestern Medical Center, Dallas, Texas, United States of America
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Emily M. Mace,

Current address: Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas, United States of America

Affiliation Children's Hospital of Philadelphia Abramson Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Danielle J. Clark,

Affiliation School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
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Alan D. Leard,

Affiliation School of Biochemistry, University of Bristol, Bristol, United Kingdom
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Andrew Herman,

Affiliation School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom
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Paul Verkade,

Affiliation School of Biochemistry, University of Bristol, Bristol, United Kingdom
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Jordan S. Orange,

Current address: Section of Immunology, Allergy, and Rheumatology, Baylor College of Medicine, Houston, Texas, United States of America

Affiliation Children's Hospital of Philadelphia Abramson Research Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Christoph Wülfing

* E-mail: Christoph.Wuelfing@bristol.co.uk

Affiliations Department of Immunology, UT Southwestern Medical Center, Dallas, Texas, United States of America, School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom, Department of Cell Biology, UT Southwestern Medical Center, Dallas, Texas, United States of America
⨯

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

Kole T. Roybal,
Emily M. Mace,
Danielle J. Clark,
Alan D. Leard,
Andrew Herman,
Paul Verkade,
Jordan S. Orange,
Christoph Wülfing

Published: August 3, 2015
https://doi.org/10.1371/journal.pone.0133231

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T cells
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Actins
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Calcium signaling
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Antigen-presenting cells
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Cell signaling
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Cell membranes
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Fluorescence recovery after photobleaching
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Phosphorylation
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