An Extended Polyanion Activation Surface in Insulin Degrading Enzyme

Eun Suk Song; Mehmet Ozbil; Tingting Zhang; Michael Sheetz; David Lee; Danny Tran; Sheng Li; Rajeev Prabhakar; Louis B. Hersh; David W. Rodgers

doi:10.1371/journal.pone.0133114

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Peer-reviewed

Research Article

An Extended Polyanion Activation Surface in Insulin Degrading Enzyme

Eun Suk Song,

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Mehmet Ozbil,

Current address: Department of Chemistry, Yale University, New Haven, Connecticut, United States of America

Affiliation Department of Chemistry, University of Miami, Miami, Florida, United States of America
⨯
Tingting Zhang,

Affiliation Department of Chemistry, University of Miami, Miami, Florida, United States of America
⨯
Michael Sheetz,

Affiliation Center for Computational Sciences, University of Kentucky, Lexington, Kentucky, United States of America
⨯
David Lee,

Affiliation Department of Medicine, University of California, San Diego, La Jolla, California, United States of America
⨯
Danny Tran,

Affiliation Department of Medicine, University of California, San Diego, La Jolla, California, United States of America
⨯
Sheng Li,

Affiliation Department of Medicine, University of California, San Diego, La Jolla, California, United States of America
⨯
Rajeev Prabhakar ,

* E-mail: david.rodgers@uky.edu (DWR); lhersh@uky.edu (LBH); rpr@miami.edu (RP)

Affiliation Department of Chemistry, University of Miami, Miami, Florida, United States of America
⨯
Louis B. Hersh ,

* E-mail: david.rodgers@uky.edu (DWR); lhersh@uky.edu (LBH); rpr@miami.edu (RP)

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
David W. Rodgers

* E-mail: david.rodgers@uky.edu (DWR); lhersh@uky.edu (LBH); rpr@miami.edu (RP)

Affiliation Department of Molecular and Cellular Biochemistry and the Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯

An Extended Polyanion Activation Surface in Insulin Degrading Enzyme

Eun Suk Song,
Mehmet Ozbil,
Tingting Zhang,
Michael Sheetz,
David Lee,
Danny Tran,
Sheng Li,
Rajeev Prabhakar,
Louis B. Hersh,
David W. Rodgers

Published: July 17, 2015
https://doi.org/10.1371/journal.pone.0133114

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Point mutation
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Enzyme structure
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Insulin
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