A Novel WRN Frameshift Mutation Identified by Multiplex Genetic Testing in a Family with Multiple Cases of Cancer

Liu Yang; Guosheng Wang; Xinyi Zhao; Song Ye; Peng Shen; Weilin Wang; Shusen Zheng

doi:10.1371/journal.pone.0133020

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Open Access

Peer-reviewed

Research Article

A Novel WRN Frameshift Mutation Identified by Multiplex Genetic Testing in a Family with Multiple Cases of Cancer

Liu Yang,

Affiliations Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China, Department of Medical Oncology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P. R. China
⨯
Guosheng Wang,

Affiliation Department of Medical Oncology, Beilun Branch of First Affiliated Hospital, School of Medicine, Zhejiang University, Ningbo, Zhejiang, P. R. China
⨯
Xinyi Zhao,

Affiliation Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, P. R. China
⨯
Song Ye,

Affiliations Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, P. R. China, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China
⨯
Peng Shen,

Affiliation Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, P. R. China
⨯
Weilin Wang,

Affiliations Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, P. R. China, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China
⨯
Shusen Zheng

* E-mail: shusenzheng@zju.edu.cn

Affiliations Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health Key Laboratory of Organ Transplantation, Hangzhou, Zhejiang, P. R. China, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, P. R. China
⨯

A Novel WRN Frameshift Mutation Identified by Multiplex Genetic Testing in a Family with Multiple Cases of Cancer

Liu Yang,
Guosheng Wang,
Xinyi Zhao,
Song Ye,
Peng Shen,
Weilin Wang,
Shusen Zheng

Published: August 4, 2015
https://doi.org/10.1371/journal.pone.0133020

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Lung and intrathoracic tumors
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Frameshift mutation
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