Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1

M. A. Suresh Kumar; Michael Peluso; Pankaj Chaudhary; Jasbeer Dhawan; Afshin Beheshti; Krishnan Manickam; Upasna Thapar; Louis Pena; Mohan Natarajan; Lynn Hlatky; Bruce Demple; Mamta Naidu

doi:10.1371/journal.pone.0133016

Loading metrics

Open Access

Peer-reviewed

Research Article

Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1

M. A. Suresh Kumar,

Affiliation Center for Radiological Research, Columbia University, New York, New York, United States of America
⨯
Michael Peluso,

Affiliation GeneSys Research Institute/ Center for Cancer Systems Biology at Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Pankaj Chaudhary,

Affiliation Centre for Cancer Research and Cell Biology, Queens University, Belfast, United Kingdom
⨯
Jasbeer Dhawan,

Affiliation Department of Psychology, Stony Brook University, Stony Brook, New York, United States of America
⨯
Afshin Beheshti,

Affiliation GeneSys Research Institute/ Center for Cancer Systems Biology at Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Krishnan Manickam,

Affiliation Department of Pathology, UTHSCSA, San Antonio, Texas, United States of America
⨯
Upasna Thapar,

Affiliation Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, United States of America
⨯
Louis Pena,

Affiliation Biosciences Department, Brookhaven National Laboratory, Upton, New York, United States of America
⨯
Mohan Natarajan,

Affiliation Department of Pathology, UTHSCSA, San Antonio, Texas, United States of America
⨯
Lynn Hlatky,

Affiliation GeneSys Research Institute/ Center for Cancer Systems Biology at Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Bruce Demple,

Affiliation Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York, United States of America
⨯
Mamta Naidu

* E-mail: mamta@cancer-systems-biology.org

Affiliation GeneSys Research Institute/ Center for Cancer Systems Biology at Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯

Fractionated Radiation Exposure of Rat Spinal Cords Leads to Latent Neuro-Inflammation in Brain, Cognitive Deficits, and Alterations in Apurinic Endonuclease 1

M. A. Suresh Kumar,
Michael Peluso,
Pankaj Chaudhary,
Jasbeer Dhawan,
Afshin Beheshti,
Krishnan Manickam,
Upasna Thapar,
Louis Pena,
Mohan Natarajan,
Lynn Hlatky

Published: July 24, 2015
https://doi.org/10.1371/journal.pone.0133016

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Protons
Is the Subject Area "Protons" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Fractionation
Is the Subject Area "Fractionation" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Inflammation
Is the Subject Area "Inflammation" applicable to this article?

Thanks for your feedback.
Astrocytes
Is the Subject Area "Astrocytes" applicable to this article?

Thanks for your feedback.
Staining
Is the Subject Area "Staining" applicable to this article?

Thanks for your feedback.