Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Han-Jin Park; Young-Jun Choi; Ji Woo Kim; Hang-Suk Chun; Ilkyun Im; Seokjoo Yoon; Yong-Mahn Han; Chang-Woo Song; Hyemin Kim

doi:10.1371/journal.pone.0132992

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Open Access

Peer-reviewed

Research Article

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Han-Jin Park,

Affiliations Department of Biological Sciences and Center for Stem Cell Differentiation, Korea Advanced Institute of Science and Technology, Daejeon, 305–701, Republic of Korea, Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305–343, Republic of Korea
⨯
Young-Jun Choi,

Affiliations Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305–343, Republic of Korea, Human and Environmental Toxicology, School of Engineering, University of Science and Technology, Daejeon, 303–333, Republic of Korea
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Ji Woo Kim,

Affiliation Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305–343, Republic of Korea
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Hang-Suk Chun,

Affiliation Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305–343, Republic of Korea
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Ilkyun Im,

Affiliation Department of Biological Sciences and Center for Stem Cell Differentiation, Korea Advanced Institute of Science and Technology, Daejeon, 305–701, Republic of Korea
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Seokjoo Yoon,

Affiliations Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305–343, Republic of Korea, Human and Environmental Toxicology, School of Engineering, University of Science and Technology, Daejeon, 303–333, Republic of Korea
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Yong-Mahn Han,

Affiliation Department of Biological Sciences and Center for Stem Cell Differentiation, Korea Advanced Institute of Science and Technology, Daejeon, 305–701, Republic of Korea
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Chang-Woo Song,

Affiliations Department of Inhalation Research, Korea Institute of Toxicology, Jeollabuk-do, 580–185, Republic of Korea, Human and Environmental Toxicology, School of Engineering, University of Science and Technology, Daejeon, 303–333, Republic of Korea
⨯
Hyemin Kim

* E-mail: hyeminkim@kitox.re.kr

Affiliation Department of Predictive Toxicology, Korea Institute of Toxicology, Daejeon, 305–343, Republic of Korea
⨯

Differences in the Epigenetic Regulation of Cytochrome P450 Genes between Human Embryonic Stem Cell-Derived Hepatocytes and Primary Hepatocytes

Han-Jin Park,
Young-Jun Choi,
Ji Woo Kim,
Hang-Suk Chun,
Ilkyun Im,
Seokjoo Yoon,
Yong-Mahn Han,
Chang-Woo Song,
Hyemin Kim

Published: July 15, 2015
https://doi.org/10.1371/journal.pone.0132992

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DNA methylation
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Hepatocytes
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Gene expression
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Gene regulation
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Epigenetics
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Cell differentiation
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Histone modification
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Polymerase chain reaction
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