Cilostazol Induces PGI₂ Production via Activation of the Downstream Epac-1/Rap1 Signaling Cascade to Increase Intracellular Calcium by PLCε and to Activate p44/42 MAPK in Human Aortic Endothelial Cells

• Ayako Hashimoto ,

  * E-mail: Hashimoto.Ayako@ostuka.jp

  Affiliation First Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima-shi, Tokushima, Japan

  ⨯
• Michinori Tanaka ,

  Contributed equally to this work with: Michinori Tanaka, Satoshi Takeda, Hideki Ito, Keisuke Nagano

  Affiliation Medical Chemistry Research Institute, Otsuka Pharmaceutical Co., Ltd. Tokushima-shi, Tokushima, Japan

  ⨯
• Satoshi Takeda ,

  Contributed equally to this work with: Michinori Tanaka, Satoshi Takeda, Hideki Ito, Keisuke Nagano

  Affiliation Qs'Research Institute, Otsuka Pharmaceutical Co., Ltd. Tokushima-shi, Tokushima, Japan

  ⨯
• Hideki Ito ,

  Contributed equally to this work with: Michinori Tanaka, Satoshi Takeda, Hideki Ito, Keisuke Nagano

  Affiliation First Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima-shi, Tokushima, Japan

  ⨯
• Keisuke Nagano

  Contributed equally to this work with: Michinori Tanaka, Satoshi Takeda, Hideki Ito, Keisuke Nagano

  Affiliation First Institute of New Drug Discovery, Otsuka Pharmaceutical Co., Ltd., Tokushima-shi, Tokushima, Japan

  ⨯