Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

Lulu Huang; Sagar S. Damle; Sheri Booten; Priyam Singh; Mahyar Sabripour; Jeff Hsu; Minji Jo; Melanie Katz; Andy Watt; Christopher E. Hart; Susan M. Freier; Brett P. Monia; Shuling Guo

doi:10.1371/journal.pone.0132798

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Open Access

Peer-reviewed

Research Article

Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

Lulu Huang,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Sagar S. Damle,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Sheri Booten,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Priyam Singh,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Mahyar Sabripour,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Jeff Hsu,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Minji Jo,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Melanie Katz,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Andy Watt,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Christopher E. Hart,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Susan M. Freier,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Brett P. Monia,

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯
Shuling Guo

* E-mail: sguo@isisph.com

Affiliation Department of Antisense Drug Discovery, Isis Pharmaceuticals Inc., Carlsbad, CA, 92010, United States of America
⨯

Partial Hepatectomy Induced Long Noncoding RNA Inhibits Hepatocyte Proliferation during Liver Regeneration

Lulu Huang,
Sagar S. Damle,
Sheri Booten,
Priyam Singh,
Mahyar Sabripour,
Jeff Hsu,
Minji Jo,
Melanie Katz,
Andy Watt,
Christopher E. Hart

Published: July 24, 2015
https://doi.org/10.1371/journal.pone.0132798

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Long non-coding RNA
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Gene expression
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Cell proliferation
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Hepatocellular carcinoma
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Messenger RNA
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Mouse models
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Hepatocytes
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Antisense RNA
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