Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis

Mehdi Shahbazi; Farnaz Zahedifard; Tahereh Taheri; Yasaman Taslimi; Shahram Jamshidi; Sadegh Shirian; Niousha Mahdavi; Mehdi Hassankhani; Yahya Daneshbod; Sayyed Hamid Zarkesh-Esfahani; Barbara Papadopoulou; Sima Rafati

doi:10.1371/journal.pone.0132794

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Open Access

Peer-reviewed

Research Article

Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis

Mehdi Shahbazi,

Affiliations Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, 69 Pasteur Ave., Tehran, 13164, Iran, Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
⨯
Farnaz Zahedifard,

Affiliation Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, 69 Pasteur Ave., Tehran, 13164, Iran
⨯
Tahereh Taheri,

Affiliation Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, 69 Pasteur Ave., Tehran, 13164, Iran
⨯
Yasaman Taslimi,

Affiliation Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, 69 Pasteur Ave., Tehran, 13164, Iran
⨯
Shahram Jamshidi,

Affiliation Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
⨯
Sadegh Shirian,

Affiliation Department of Molecular and Cytopathology, Daneshbod Pathology Laboratory, Shiraz, Iran
⨯
Niousha Mahdavi,

Affiliation Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
⨯
Mehdi Hassankhani,

Affiliation Department of Internal Medicine, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
⨯
Yahya Daneshbod,

Affiliation Department of Molecular and Cytopathology, Daneshbod Pathology Laboratory, Shiraz, Iran
⨯
Sayyed Hamid Zarkesh-Esfahani,

Affiliation Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
⨯
Barbara Papadopoulou,

Affiliation Research Center in Infectious Diseases, CHU de Québec Research Center and Department of Microbiology, Infectious Disease and Immunology, Laval University, Quebec, QC, Canada
⨯
Sima Rafati

* E-mail: s_rafati@yahoo.com

Affiliation Department of Immunotherapy and Leishmania Vaccine Research, Pasteur Institute of Iran, 69 Pasteur Ave., Tehran, 13164, Iran
⨯

Evaluation of Live Recombinant Nonpathogenic Leishmania tarentolae Expressing Cysteine Proteinase and A2 Genes as a Candidate Vaccine against Experimental Canine Visceral Leishmaniasis

Mehdi Shahbazi,
Farnaz Zahedifard,
Tahereh Taheri,
Yasaman Taslimi,
Shahram Jamshidi,
Sadegh Shirian,
Niousha Mahdavi,
Mehdi Hassankhani,
Yahya Daneshbod,
Sayyed Hamid Zarkesh-Esfahani

Published: July 21, 2015
https://doi.org/10.1371/journal.pone.0132794

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