Chronic Losartan Treatment Up-Regulates AT1R and Increases the Heart Vulnerability to Acute Onset of Ischemia and Reperfusion Injury in Male Rats

Open Access

Peer-reviewed

Research Article

Chronic Losartan Treatment Up-Regulates AT₁R and Increases the Heart Vulnerability to Acute Onset of Ischemia and Reperfusion Injury in Male Rats

Minwoo A. Song,

Affiliation Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States of America
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Chiranjib Dasgupta,

Affiliation Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States of America
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Lubo Zhang

* E-mail: lzhang@llu.edu

Affiliation Center for Perinatal Biology, Division of Pharmacology, Department of Basic Sciences, Loma Linda University School of Medicine, Loma Linda, CA, United States of America
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Heart
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Cardiac ventricles
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Ischemia
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Reperfusion injury
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Reperfusion
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Body weight
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ACE inhibitor therapy
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Blood pressure
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