Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats

Ning Zhang; Hanyu Liang; Robert V. Farese; Ji Li; Nicolas Musi; Sophie E. Hussey

doi:10.1371/journal.pone.0132575

Loading metrics

Open Access

Peer-reviewed

Research Article

Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats

Ning Zhang,

Affiliation Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States of America
⨯
Hanyu Liang,

Affiliations Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States of America, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States of America, The Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, 78229, United States of America
⨯
Robert V. Farese,

Affiliations Department of Internal Medicine, The University of South Florida, Tampa, FL 33620, United States of America, James A Hayley Veterans Medical Center, Tampa, FL, 33612, United States of America
⨯
Ji Li,

Affiliations Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States of America, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States of America
⨯
Nicolas Musi ,

Contributed equally to this work with: Nicolas Musi, Sophie E. Hussey

* E-mail: sophiehussey@icloud.com (SHE); musi@uthscsa.edu (NM)

Affiliations Barshop Institute for Longevity and Aging Studies, The University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States of America, Department of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, United States of America, The Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, 78229, United States of America
⨯
Sophie E. Hussey

Contributed equally to this work with: Nicolas Musi, Sophie E. Hussey

* E-mail: sophiehussey@icloud.com (SHE); musi@uthscsa.edu (NM)

Affiliations Department of Internal Medicine, The University of South Florida, Tampa, FL 33620, United States of America, James A Hayley Veterans Medical Center, Tampa, FL, 33612, United States of America
⨯

Pharmacological TLR4 Inhibition Protects against Acute and Chronic Fat-Induced Insulin Resistance in Rats

Ning Zhang,
Hanyu Liang,
Robert V. Farese,
Ji Li,
Nicolas Musi,
Sophie E. Hussey

Published: July 21, 2015
https://doi.org/10.1371/journal.pone.0132575

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.
Lipids
Is the Subject Area "Lipids" applicable to this article?

Thanks for your feedback.
Glucose
Is the Subject Area "Glucose" applicable to this article?

Thanks for your feedback.
Insulin resistance
Is the Subject Area "Insulin resistance" applicable to this article?

Thanks for your feedback.
Body weight
Is the Subject Area "Body weight" applicable to this article?

Thanks for your feedback.
Obesity
Is the Subject Area "Obesity" applicable to this article?

Thanks for your feedback.
Toll-like receptors
Is the Subject Area "Toll-like receptors" applicable to this article?

Thanks for your feedback.
Diet
Is the Subject Area "Diet" applicable to this article?

Thanks for your feedback.