Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption

Zhong-Yuan Ren; Irma Machuca-Gayet; Chantal Domenget; Rene Buchet; Yuqing Wu; Pierre Jurdic; Saida Mebarek

doi:10.1371/journal.pone.0132513

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Peer-reviewed

Research Article

Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption

Zhong-Yuan Ren,

Affiliations State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China, Université de Lyon, Villeurbanne F-69622, France, Université Lyon 1, Villeurbanne F-69622, France, CPE Lyon, Villeurbanne F-69622, France, INSA-Lyon, Villeurbanne F-69622, France, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, Villeurbanne F-69622, France, CNRS UMR 5246, Villeurbanne F-69622, France
⨯
Irma Machuca-Gayet,

Affiliations Université de Lyon, Villeurbanne F-69622, France, Université Lyon 1, Villeurbanne F-69622, France, Ecole Normale Supérieure de Lyon, Lyon F-69634 France, Institut de Génomique Fonctionnelle de Lyon, Lyon F-69634 France, CNRS UMR3444, Lyon F-69634 France
⨯
Chantal Domenget,

Affiliations Université de Lyon, Villeurbanne F-69622, France, Université Lyon 1, Villeurbanne F-69622, France, Ecole Normale Supérieure de Lyon, Lyon F-69634 France, Institut de Génomique Fonctionnelle de Lyon, Lyon F-69634 France, CNRS UMR3444, Lyon F-69634 France
⨯
Rene Buchet,

Affiliations Université de Lyon, Villeurbanne F-69622, France, Université Lyon 1, Villeurbanne F-69622, France, CPE Lyon, Villeurbanne F-69622, France, INSA-Lyon, Villeurbanne F-69622, France, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, Villeurbanne F-69622, France, CNRS UMR 5246, Villeurbanne F-69622, France
⨯
Yuqing Wu,

Affiliation State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China
⨯
Pierre Jurdic,

Affiliations Université de Lyon, Villeurbanne F-69622, France, Université Lyon 1, Villeurbanne F-69622, France, Ecole Normale Supérieure de Lyon, Lyon F-69634 France, Institut de Génomique Fonctionnelle de Lyon, Lyon F-69634 France, CNRS UMR3444, Lyon F-69634 France
⨯
Saida Mebarek

* E-mail: saida.youjil@univ-lyon1.fr

Affiliations Université de Lyon, Villeurbanne F-69622, France, Université Lyon 1, Villeurbanne F-69622, France, CPE Lyon, Villeurbanne F-69622, France, INSA-Lyon, Villeurbanne F-69622, France, Institut de Chimie et de Biochimie Moléculaires et Supramoléculaires, Villeurbanne F-69622, France, CNRS UMR 5246, Villeurbanne F-69622, France
⨯

Azanitrile Cathepsin K Inhibitors: Effects on Cell Toxicity, Osteoblast-Induced Mineralization and Osteoclast-Mediated Bone Resorption

Zhong-Yuan Ren,
Irma Machuca-Gayet,
Chantal Domenget,
Rene Buchet,
Yuqing Wu,
Pierre Jurdic,
Saida Mebarek

Published: July 13, 2015
https://doi.org/10.1371/journal.pone.0132513

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