PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury

Weiwei Wu; Hao Xu; Zemin Wang; Yun Mao; Liangshuai Yuan; Wei Luo; Zhaoqiang Cui; Taixing Cui; Xing Li Wang; Ying H. Shen

doi:10.1371/journal.pone.0132499

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Open Access

Peer-reviewed

Research Article

PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury

Weiwei Wu,

Affiliation Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China
⨯
Hao Xu,

Affiliation Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China
⨯
Zemin Wang,

Affiliation Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China
⨯
Yun Mao,

Affiliation Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China
⨯
Liangshuai Yuan,

Affiliation Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China
⨯
Wei Luo,

Affiliation Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China
⨯
Zhaoqiang Cui,

Affiliation Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China
⨯
Taixing Cui,

Affiliations Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China, Department of Cell Biology and Anatomy, South Carolina University, Columbus, South Carolina29209, United States of America
⨯
Xing Li Wang ,

* E-mail: hyshen@bcm.edu (YHS); xingliwang@sdu.edu.cn (XLW)

Affiliations Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan 250012, P.R. China, Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States of America, Texas Heart Institute, Houston, TX, United States of America
⨯
Ying H. Shen

* E-mail: hyshen@bcm.edu (YHS); xingliwang@sdu.edu.cn (XLW)

Affiliations Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States of America, Texas Heart Institute, Houston, TX, United States of America
⨯

PINK1-Parkin-Mediated Mitophagy Protects Mitochondrial Integrity and Prevents Metabolic Stress-Induced Endothelial Injury

Weiwei Wu,
Hao Xu,
Zemin Wang,
Yun Mao,
Liangshuai Yuan,
Wei Luo,
Zhaoqiang Cui,
Taixing Cui,
Xing Li Wang,
Ying H. Shen

Published: July 10, 2015
https://doi.org/10.1371/journal.pone.0132499

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