Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats

Julia A. Sharp; Pamela S. Hair; Haree K. Pallera; Parvathi S. Kumar; Clifford T. Mauriello; Julius O. Nyalwidhe; Cody A. Phelps; Dalnam Park; Nicole M. Thielens; Stephen M. Pascal; Waldon Chen; Diane M. Duffy; Frank A. Lattanzio; Kenji M. Cunnion; Neel K. Krishna

doi:10.1371/journal.pone.0132446

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Peer-reviewed

Research Article

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats

Julia A. Sharp,

Affiliation Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Pamela S. Hair,

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Haree K. Pallera,

Affiliation Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Parvathi S. Kumar,

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Clifford T. Mauriello,

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Julius O. Nyalwidhe,

Affiliations Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, The Leroy T. Canoles Jr. Cancer Research Center, Norfolk, Virginia, United States of America
⨯
Cody A. Phelps,

Affiliation Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Dalnam Park,

Affiliation Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
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Nicole M. Thielens,

Affiliations Univ. Grenoble Alpes, IBS, F-38044, Grenoble, France, CNRS, IBS, F-38044, Grenoble, France, CEA, IBS, F-38044, Grenoble, France
⨯
Stephen M. Pascal,

Affiliation Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, United States of America
⨯
Waldon Chen,

Affiliation Department of Chemistry and Biochemistry, Old Dominion University, Norfolk, Virginia, United States of America
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Diane M. Duffy,

Affiliation Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯
Frank A. Lattanzio,

Affiliation Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
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Kenji M. Cunnion,

Affiliations Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Children’s Specialty Group, Norfolk, Virginia, United States of America
⨯
Neel K. Krishna

* E-mail: krishnnk@evms.edu

Affiliations Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia, United States of America, Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
⨯

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats

Julia A. Sharp,
Pamela S. Hair,
Haree K. Pallera,
Parvathi S. Kumar,
Clifford T. Mauriello,
Julius O. Nyalwidhe,
Cody A. Phelps,
Dalnam Park,
Nicole M. Thielens,
Stephen M. Pascal

Published: July 21, 2015
https://doi.org/10.1371/journal.pone.0132446

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