Functional Characterization of a Ketoreductase-Encoding Gene med-ORF12 Involved in the Formation of a Stereospecific Pyran Ring during the Biosynthesis of an Antitumor Antibiotic Medermycin

Open Access

Peer-reviewed

Research Article

Qiang He,

Affiliations State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University-Helmholtz Institute of Biotechnology, Shandong University, Jinan, China, School of Life Sciences, Central China Normal University, Wuhan, China
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Le Li,

Affiliation School of Life Sciences, Central China Normal University, Wuhan, China
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Tingting Yang,

Affiliations State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University-Helmholtz Institute of Biotechnology, Shandong University, Jinan, China, School of Life Sciences, Central China Normal University, Wuhan, China
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Ruijuan Li,

Affiliation State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University-Helmholtz Institute of Biotechnology, Shandong University, Jinan, China
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Aiying Li

* E-mail: aiyli@126.com

Affiliations State Key Laboratory of Microbial Technology, School of Life Sciences, Shandong University-Helmholtz Institute of Biotechnology, Shandong University, Jinan, China, School of Life Sciences, Central China Normal University, Wuhan, China
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Streptomyces
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Mutant strains
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Plasmid construction
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Polymerase chain reaction
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Biosynthesis
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Antibiotics
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Genomics
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Phylogenetic analysis
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