Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis

Cristiano Xavier Lima; Danielle Gloria Souza; Flavio Almeida Amaral; Caio Tavares Fagundes; Irla Paula Stopa Rodrigues; Jose Carlos Alves-Filho; Marie Kosco-Vilbois; Walter Ferlin; Limin Shang; Greg Elson; Mauro Martins Teixeira

doi:10.1371/journal.pone.0132336

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Open Access

Peer-reviewed

Research Article

Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis

Cristiano Xavier Lima ,

* E-mail: cristianoxlima@gmail.com

Affiliation Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 190, sala 203, 30130–100, Belo Horizonte, MG, Brasil
⨯
Danielle Gloria Souza,

Affiliation Instituto de Ciências Biologicas, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, 31270–901, Belo Horizonte, MG, Brasil
⨯
Flavio Almeida Amaral,

Affiliation Instituto de Ciências Biologicas, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, 31270–901, Belo Horizonte, MG, Brasil
⨯
Caio Tavares Fagundes,

Affiliation Instituto de Ciências Biologicas, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, 31270–901, Belo Horizonte, MG, Brasil
⨯
Irla Paula Stopa Rodrigues,

Affiliation Instituto de Ciências Biologicas, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, 31270–901, Belo Horizonte, MG, Brasil
⨯
Jose Carlos Alves-Filho,

Affiliation Faculdade de Medicina de Ribeirão Preto, USP Avenida dos Bandeirantes, 3.900, Monte Alegre, 14049–900, Ribeirão Preto, SP, Brasil
⨯
Marie Kosco-Vilbois,

Affiliation NovImmune SA, 14 Chemin des Aulx, 1228 Plan-Les-Ouates, Geneva, CH1228, Switzerland
⨯
Walter Ferlin,

Affiliation NovImmune SA, 14 Chemin des Aulx, 1228 Plan-Les-Ouates, Geneva, CH1228, Switzerland
⨯
Limin Shang,

Affiliation NovImmune SA, 14 Chemin des Aulx, 1228 Plan-Les-Ouates, Geneva, CH1228, Switzerland
⨯
Greg Elson,

Affiliation NovImmune SA, 14 Chemin des Aulx, 1228 Plan-Les-Ouates, Geneva, CH1228, Switzerland
⨯
Mauro Martins Teixeira

Affiliations Faculdade de Medicina, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena 190, sala 203, 30130–100, Belo Horizonte, MG, Brasil, Instituto de Ciências Biologicas, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos 6627, 31270–901, Belo Horizonte, MG, Brasil
⨯

Therapeutic Effects of Treatment with Anti-TLR2 and Anti-TLR4 Monoclonal Antibodies in Polymicrobial Sepsis

Cristiano Xavier Lima,
Danielle Gloria Souza,
Flavio Almeida Amaral,
Caio Tavares Fagundes,
Irla Paula Stopa Rodrigues,
Jose Carlos Alves-Filho,
Marie Kosco-Vilbois,
Walter Ferlin,
Limin Shang,
Greg Elson

Published: July 6, 2015
https://doi.org/10.1371/journal.pone.0132336

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