Site-Dependent Degradation of a Non-Cleavable Auristatin-Based Linker-Payload in Rodent Plasma and Its Effect on ADC Efficacy

• Magdalena Dorywalska ,

  Contributed equally to this work with: Magdalena Dorywalska, Pavel Strop

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Pavel Strop ,

  Contributed equally to this work with: Magdalena Dorywalska, Pavel Strop

  * E-mail: pavel.strop@pfizer.com

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Jody A. Melton-Witt,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Adela Hasa-Moreno,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Santiago E. Farias,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Meritxell Galindo Casas,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Kathy Delaria,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Victor Lui,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Kris Poulsen,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Janette Sutton,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Gary Bolton,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Dahui Zhou,

  Affiliation Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America

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• Ludivine Moine,

  Affiliation Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America

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• Russell Dushin,

  Affiliation Worldwide Medicinal Chemistry, Pfizer Inc., 445 Eastern Point Road, Groton, CT, 06340, United States of America

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• Thomas-Toan Tran,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Shu-Hui Liu,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Mathias Rickert,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Davide Foletti,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• David L. Shelton,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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• Jaume Pons,

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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•  [ ... ],
• Arvind Rajpal

  Affiliation Rinat Laboratories, Pfizer Inc., 230 East Grand Avenue, South San Francisco, CA, 94080, United States of America

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