Mutations Causing Complex Disease May under Certain Circumstances Be Protective in an Epidemiological Sense

• Sabine Siegert,

  Affiliations Cologne Center for Genomics, University of Cologne, Cologne, Germany, Institute of Epidemiology, Christian-Albrechts University, Kiel, Germany

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• Andreas Wolf,

  Affiliation Institute of Medical Informatics and Statistics, Christian-Albrechts University, Kiel, Germany

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• David N. Cooper,

  Affiliation Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom

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• Michael Krawczak ,

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Institute of Medical Informatics and Statistics, Christian-Albrechts University, Kiel, Germany

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• Michael Nothnagel

  * E-mail: michael.nothnagel@uni-koeln.de

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Cologne Center for Genomics, University of Cologne, Cologne, Germany, Institute of Medical Informatics and Statistics, Christian-Albrechts University, Kiel, Germany

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