Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice

• Changshan Wang,

  Affiliations Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan, College of Life Sciences, Inner Mongolia University, Hohhot 010021, China

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• Motohiko Oshima,

  Affiliation Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan

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• Goro Sashida,

  Affiliations Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan, International Research Center for Medical Sciences, Kumamoto University, Kumamoto City 860–0811, Japan

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• Takahisa Tomioka,

  Affiliation Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan

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• Nagisa Hasegawa,

  Affiliations Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan, Department of Hematology, Chiba University Hospital, Chiba 260–8670, Japan

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• Makiko Mochizuki-Kashio,

  Affiliation Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan

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• Yaeko Nakajima-Takagi,

  Affiliation Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan

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• Yoichiro Kusunoki,

  Affiliation Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732–0815, Japan

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• Seishi Kyoizumi,

  Affiliation Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732–0815, Japan

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• Kazue Imai,

  Affiliation Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732–0815, Japan

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• Kei Nakachi,

  Affiliation Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732–0815, Japan

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• Atsushi Iwama

  * E-mail: aiwama@faculty.chiba-u.jp

  Affiliation Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba 260–8670, Japan

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