Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes

• Yonghui Jin ,

  Contributed equally to this work with: Yonghui Jin, Hassan Elalaf

  Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Hassan Elalaf ,

  Contributed equally to this work with: Yonghui Jin, Hassan Elalaf

  Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Makoto Watanabe,

  Affiliations Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Life Science Research Center, Shimadzu Cooperation, Kyoto, Japan

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• Sakura Tamaki,

  Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Sho Hineno,

  Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Kazuhito Matsunaga,

  Affiliations Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Department of Gastroenterology and Hepatology, Graduate School of Medicine, Yamaguchi University, Ube, Japan

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• Knut Woltjen,

  Affiliation Department of Reprogramming Sciences, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

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• Yukiko Kobayashi,

  Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Sanae Nagata,

  Affiliation Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

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• Makoto Ikeya,

  Affiliation Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

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• Tomohisa Kato Jr,

  Affiliation Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan

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• Takeshi Okamoto,

  Affiliation Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Shuichi Matsuda,

  Affiliation Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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• Junya Toguchida

  * E-mail: togjun@frontier.kyoto-u.ac.jp

  Affiliations Department of Tissue Regeneration, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan, Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan

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