The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core

Zhao Jiang; Lora Talley Watts; Shiliang Huang; Qiang Shen; Pavel Rodriguez; Chunhua Chen; Changman Zhou; Timothy Q. Duong

doi:10.1371/journal.pone.0131929

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Open Access

Peer-reviewed

Research Article

The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core

Zhao Jiang,

Affiliations Department of Anatomy and Embryology, Peking University Health Science Center, Beijing, China, Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Lora Talley Watts,

Affiliation Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Shiliang Huang,

Affiliation Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Qiang Shen,

Affiliation Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Pavel Rodriguez,

Affiliation Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯
Chunhua Chen,

Affiliations Department of Anatomy and Embryology, Peking University Health Science Center, Beijing, China, Department of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Changman Zhou,

Affiliation Department of Anatomy and Embryology, Peking University Health Science Center, Beijing, China
⨯
Timothy Q. Duong

* E-mail: DuongT@uthscsa.edu

Affiliation Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
⨯

The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core

Zhao Jiang,
Lora Talley Watts,
Shiliang Huang,
Qiang Shen,
Pavel Rodriguez,
Chunhua Chen,
Changman Zhou,
Timothy Q. Duong

Published: June 29, 2015
https://doi.org/10.1371/journal.pone.0131929

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Apoptosis
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Autophagic cell death
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Ischemic stroke
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Magnetic resonance imaging
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Methylene blue
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Apoptotic signaling cascade
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