Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

Rana Rais; Krystyna Wozniak; Ying Wu; Minae Niwa; Marigo Stathis; Jesse Alt; Marc Giroux; Akira Sawa; Camilo Rojas; Barbara S. Slusher

doi:10.1371/journal.pone.0131861

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Peer-reviewed

Research Article

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

Rana Rais,

Affiliations Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Krystyna Wozniak,

Affiliation Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Ying Wu,

Affiliation Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Minae Niwa,

Affiliation Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Marigo Stathis,

Current Address: Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America

Affiliation Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Jesse Alt,

Affiliation Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Marc Giroux,

Affiliation Kurve Technology, Inc., Bothell, Washington, United States of America
⨯
Akira Sawa,

Affiliation Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Camilo Rojas,

Affiliations Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯
Barbara S. Slusher

* E-mail: bslusher@jhmi.edu

Affiliations Brain Science Institute, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, Maryland, United States of America
⨯

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration

Rana Rais,
Krystyna Wozniak,
Ying Wu,
Minae Niwa,
Marigo Stathis,
Jesse Alt,
Marc Giroux,
Akira Sawa,
Camilo Rojas,
Barbara S. Slusher

Published: July 7, 2015
https://doi.org/10.1371/journal.pone.0131861

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