miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways

Alexandre K. Rouquette-Jazdanian; Robert L. Kortum; Wenmei Li; Robert K. Merrill; Phan H. Nguyen; Lawrence E. Samelson; Connie L. Sommers

doi:10.1371/journal.pone.0131823

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Peer-reviewed

Research Article

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways

Alexandre K. Rouquette-Jazdanian,

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Robert L. Kortum,

Current Address: Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Wenmei Li,

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Robert K. Merrill,

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Phan H. Nguyen,

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Lawrence E. Samelson,

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Connie L. Sommers

* E-mail: sommersc@mail.nih.gov (CLS)

Affiliation Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways

Alexandre K. Rouquette-Jazdanian,
Robert L. Kortum,
Wenmei Li,
Robert K. Merrill,
Phan H. Nguyen,
Lawrence E. Samelson,
Connie L. Sommers

Published: June 29, 2015
https://doi.org/10.1371/journal.pone.0131823

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