Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency

Ana Sofia Rodrigues; Marcelo Correia; Andreia Gomes; Sandro L. Pereira; Tânia Perestrelo; Maria Inês Sousa; João Ramalho-Santos

doi:10.1371/journal.pone.0131663

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Peer-reviewed

Research Article

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency

Ana Sofia Rodrigues,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
⨯
Marcelo Correia,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal
⨯
Andreia Gomes,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal, Biocant—Center of Innovation in Biotechnology, Cantanhede, Portugal
⨯
Sandro L. Pereira,

Affiliation CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal
⨯
Tânia Perestrelo,

Affiliations PhD Programme in Experimental Biology and Biomedicine, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Institute for Interdisciplinary Research (IIIUC), University of Coimbra, Coimbra, Portugal
⨯
Maria Inês Sousa,

Affiliations CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, University of Coimbra, Coimbra, Portugal
⨯
João Ramalho-Santos

* E-mail: jramalho@ci.uc.pt

Affiliations CNC—Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, Department of Life Sciences, University of Coimbra, Coimbra, Portugal
⨯

Dichloroacetate, the Pyruvate Dehydrogenase Complex and the Modulation of mESC Pluripotency

Ana Sofia Rodrigues,
Marcelo Correia,
Andreia Gomes,
Sandro L. Pereira,
Tânia Perestrelo,
Maria Inês Sousa,
João Ramalho-Santos

Published: July 6, 2015
https://doi.org/10.1371/journal.pone.0131663

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Pluripotency
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Cell differentiation
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Cell metabolism
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Mitochondria
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Glycolysis
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Pyruvate
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Drug metabolism
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Glucose metabolism
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